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High end mass spectrometer
LCMS-IT-TOF is the latest high-end mass spectrometer launched by Shimadzu Corporation. LCMS-IT-TOF is a hybrid mass spectrometer with a unique ion tra
Product details
Product IntroductionLCMS-IT-TOF can be widely applied in the structural analysis of organic small molecules, identification of traditional Chinese medicine components, proteomics research of food, spices, pesticide residues, and biomacromolecules, including primary de novo sequencing of peptides, protein identification, post transcriptional modification, analysis of complex glycoproteins, etc. Among them, the prediction of unknown compound molecular formulas is its most distinctive function. Due to the ability to achieve multi-stage mass spectrometry while maintaining high quality accuracy, the multi-stage fragment information of organic small molecules can be fully utilized to accurately infer elemental composition. Thus, the chemical formula of the unknown compound can be quickly obtained. Such powerful functionality is impossible to achieve in many existing high-end mass spectrometers.- The workstation software LCMS solution of LCMS-IT-TOF is built on the LabSolution platform commonly used by Shimadzu, and the control software for many of Shimadzu's analytical instruments is developed based on LabSolution. Such as high-performance liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography, gas chromatography-mass spectrometry, and so on. The user interface of this software is very user-friendly, and users can quickly master its operation. The LCMS solution used for LCMS-IT-TOF achieves comprehensive control over the powerful functions of LCMS-IT-TOF.
main features - The ability of ten level mass spectrometry
Due to significant signal attenuation during multi-stage mass spectrometry in traditional ion traps, only three to four stage mass spectrometry can usually be performed. The ion trap of LCMS-IT-TOF has been uniquely designed to effectively suppress signal attenuation during multi-stage mass spectrometry, achieving better multi-stage mass spectrometry capability than traditional ion traps. It can achieve the analytical capability of ten level mass spectrometry. - Each level of MSn can ensure high-quality accuracy
LCMS-IT-TOF is the only mass spectrometer in the world that can ensure high-quality accuracy for each stage of MS, which is completely impossible for traditional Q-TOF and ion trap mass spectrometry. - Each level of MSn mass spectrometry can achieve high resolution, high quality accuracy, and high sensitivity simultaneously
Can simultaneously obtain high-resolution and high-quality precision MS, MS/MS, MS/MS/MS 。。。 MSn's data, all of these modes use unique DSR (Secondary Reflector) and BIE (Ballistic Ion Extraction Technology) patents. And it can use CCI technology to capture all chromatographic peaks eluted by LC as much as possible (compressed ion implantation method, Japanese Patent No.) - Excellent quality stability
The entire instrument is equipped with complete internal temperature control function (including flight tube), ensuring high stability of ion flight distance and ion acceleration voltage (which are factors affecting mass stability). This means that very good quality stability can be achieved in more levels of MS analysis. The same batch of samples can work continuously for a week as long as they are compared to the standard sample, and the quality accuracy can be maintained within 5ppm, which is difficult to achieve with other TOF type instruments. - High speed switching between positive ion mode and negative ion mode
During the injection process of a sample, information on both positive and negative ion modes can be obtained simultaneously. It only takes 0.1 seconds to automatically switch and scan between the positive and negative ion modes of MS1, and to switch and scan between the positive and negative ion modes of MSn. Especially for the structural identification of unknown substances, performing positive ion mode and negative ion mode can obtain more reliable mass spectrometry analysis results. Despite the short switching time between positive and negative ion modes, high-quality accuracy can still be ensured. - Automatic MS/MS analysis function, which can automatically switch from MS to MSn measurement during the measurement process
In MS/MS determination, it is necessary to select the parent ion and then select the parent ion from the fragment ions. This instrument can automatically select parent ions and select parent ions from fragment ions based on specific parameter settings. For the detection of unknown substances, if the mass number of the parent ion is not known in advance, the parent ion can automatically perform MS/MS function, thus enabling effective analysis. - Equipped with automatic tuning function
The instrument is equipped with automatic calibration function to calibrate the operation of MS and optimize the calibration of MS axis. The operating parameters of complex MS instruments, including MS related parts, can be optimized through complex automatic operations. - Powerful molecular formula prediction software Formula Predictor
Formula Predictor can accurately and quickly predict molecular formulas based on precise mass identification and multi-level mass spectrometry information. Compared with other similar software instruments, Formula Predictor fully facilitates multi-level mass spectrometry information, achieving unprecedented accuracy in structural identification. - Protein identification software ProteinLayer
This software can seamlessly connect with the operating software of the instrument. If used in conjunction with a protein identification database, data acquisition, data post-processing, peptide mass spectrometry peak selection, database retrieval, protein identification can be completed with just one click of the mouse. It is highly automated and suitable for high-throughput proteomics research.
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